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g., creatinine clearance < 30 mL/min), and concomitant use of erythromycin or potent CYP3A4 inhibitors, plasma levels of sildenafil at 24 several hours publish dose are actually identified to generally be 3 to eight occasions bigger than Individuals found in healthful volunteers. Whilst plasma amounts of sildenafil at 24 several hours submit dose tend to be reduced than at peak focus, it truly is unknown no matter if nitrates may be safely and securely co-administered at this time position [see CONTRAINDICATIONS].

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